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We report a method for the detection and quantitation of 12 drugs and 2 metabolites in the same structural class as the illicit mu-opioid agonist U-47700 in human whole blood. These substances are either known or suspected to be present as potential novel opioids in illicit drug markets. The general class of these drugs was developed in pharmaceutical research programs in the 1970s, but these drugs have recently become of concern for overdoses and death in opioid users in the USA and internationally. The scope of analysis included the following compounds: methylenedioxy U-47700, ethylenedioxy U-47700, ethylenedioxy U-51754, U-69593, U-47931E (bromadoline), U-47700, U-48800, U-49900, U-51754, U-50488, propyl U-47700 and isopropyl U-47700. Additionally, two metabolites N,N-didesmethyl U-47700 and desmethyl U-47700 were also included in the scope. Drugs were extracted from human whole blood using solid-phase extraction, and the extracts were analyzed by liquid chromatography--tandem mass spectrometry. The assay was validated with respect to bias, carryover, interference, within-run and between-run precision, and accuracy. Eight medicolegal death investigation cases that had screened positive for U-48800 by liquid chromatography--time-of-flight mass spectrometry were successfully confirmed and quantified using this method. The mean and median concentrations of U-48800 in these cases were 2.5 (2.1) and 1.8 ng/mL, respectively, with a range of concentrations of 0.27-6.2 ng/mL. Case history information including the presence of other drugs in combination are described and discussed.
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U-48800 (Item No. 22278) is an analytical reference material that is structurally similar to known opioids. This product is intended for research and forensic applications. This product is a qualified Reference Material (RM) that has been manufactur...
U-48800 U-48800 is an analog of U-47700 and U-48800 is an opiod analgesic. U-48800 is an analog of U-47700 which one methylene has been added on the benzene ring. U-48800 appears to be a white powder with the chemical formular of C16H22C12N20.The molecular weight of U-48800 is 329.27g/mol and the purity is over 99%. The 2,4 Dichlorophenyl replaced the 3,4 dichlorophenyl receptor ,so U-48800 is having 7 times the potency of morphine. A small history of U-48800 shows that it appeared in the market in 2017 and U-48800 was developed by a team at upjohn in the 1970s . U-48800 is also known as pink or Heroin.
Amends GS 90-89, modifying and adding to the Schedule I controlled substances. Adds to the Schedule I opiates Isopropyl-U-47700, U-51754, and U-48800, as specified, as well as Isotonitazene, Metonitazene, and Brorphine. Also specifies that the isomers of levophenacyclmorphan, included as a Schedule I opiate, includes optical and geometric isomers. Qualifies the fentanyl derivatives included in the Schedule to include any compound as previously described unless specifically excepted, listed in another schedule, or contained within a pharmaceutical product approved by the US FDA. Provides that the opium derivatives included in the Schedule include the derivatives' optical, positional, or geometric isomer. Provides that the hallucinogenic substances included in the Schedule include the substances' optical, positional, or geometric isomers. Adds substituted tryptamines and substituted phenylcyclohexylamines, as defined, to the hallucinogenic substances included in the Schedule. Adds Clonazolam, Flualprazolam and Flubromazolam to the substances included under systemic depressants. Specifies that the isomers of mephedrone, MDPV, and substituted cathinones, all included as a Schedule I stimulant, include optical, positional, or geometric isomers. Specifies that the isomers of NBOMe compounds, a Schedule I controlled substance, include optical, positional, or geometric isomers. Adds substituted phenethylamines and N-Benzyl Phenethylamines, as defined, to Schedule I controlled substances.
The below information is copied from internet,you can check at reddit r/rcbestsell for more information find out if it is fit to your research! not human consumption!U-48800 is an opioid analgesic drug analogue of originally U-47700,just added one methylene on the benzene ring,at the same time, 2,4-dichlorophenyl replaced the 3,4-dichlorophenyl. U-48800 is selective for the µ-opioid receptor, having around 7.5 x the potency of morph in animal models. Research results shows that U-48800 has the same potency level as originally U-47700. Use for laboratory research only, not for human consumption.
Buy U-48800 Online. U-48800 is a highly potent opioid chemical that acts as a selective agonist. U-48800 not structurally related to fentanyl. U-48800 is an analog of U-47700, just added one methylene on the benzene ring, at the same time, 2,4-dichlorophenyl replaced the 3,4-dichlorophenyl.
U-48800 has formal name: 2-(2,4-dichlorophenyl)-N-((2S)-2-(dimethylamino)cyclohexyl)-N-methylacetamide. The chemical formula for U-48800 is C17H24Cl2N2O with a molecular weight of 343.291
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U-48800 is an analytical reference material that is structurally similar to known opioids. This product is intended for research and forensic applications. This product is a qualified Reference Material (RM) that has been manufactured and tested to meet ISO/IEC 17025 and ISO Guide 34 guidelines. These materials are tested using validated analytical methods on qualified instrumentation to ensure traceability of measurements. All traceable RMs may be distinguished by their CofAs and can be downloaded below using the batch number located on the product label. For a representative CofA please contact our technical support. WARNING This product is not for human or veterinary use.
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U-48800 available to be purchased on the web Buy u-48800 on the webThere are no logical references concerning physiological and toxicological properties of this examination synthetic. Subsequently, it very well might be perilous for individuals and creatures and should be utilized distinctly in certificated labs for scientific or research points. U-48800 has a place with narcotic analgesics, thus its capability to shaping reliance is exceptionally high. This examination synthetic can go under US Analog Federal Act, since it is firmly connected with U-47700, which is a Schedule I drug in the United States. Thusly, you should ensure that it is legitimate in your nation or area to purchase U-48800 on the web.
U-48800 is classified as a novel opioid of the trans-N-[2-(methylamino)cyclohexyl]-benzamide class. Novel opioids have been reported to cause effects similar to heroin and fentanyl. Novel opioids in the trans-N-[2-(methylamino)cyclohexyl]-benzamide class, such as U-47700 and U-49900, have caused adverse events, including deaths, as described in the literature. Structurally similar compounds include U-47700 and U-49900.
U-48800 is a designer chemical similar to the opioid class, intended for chemical research and forensic examinations.U-48800 is produced on modern chemical equipment in compliance with all standards, which makes this chemical as clean and quality as possible.
Buy U-48800 (hydrochloride) is an analytical reference material that is structurally similar to known opioids. This product is intended for research and forensic applications.This product is a qualified Reference Material (RM) that has been manufactured and tested to meet ISO/IEC 17025 and ISO Guide 34 guidelines. These materials are tested using validated analytical methods on qualified instrumentation to ensure traceability of measurements.
U-48800 is a highly potent opioid agonist, not structurally related to fentanyl, that has been confirmed in opioid overdoses and deaths. Novel synthetic opioids (NSOs) created to circumvent drug control laws such as U-48800 have no recognized therapeutic use, are clandestinely manufactured and sold on conventional or dark web. This Certified Spiking Solution is applicable for use in urine drug testing, clinical toxicology, or forensic analysis applications by LC-MS/MS or GC/MS.
U-48800 is ahighly potent opioid chemical that acts as a selective agonist. U-48800 not structurally related to fentanyl. U-48800 is an analog of U-47700, just added one methylene on the benzene ring,at the same time, 2,4-dichlorophenyl replaced the 3,4-dichlorophenyl.
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